研究员 博士生导师
基本信息
办公电话：021-51322408
电子邮箱：izhangdd@126.com
通讯地址：上海市浦东新区蔡伦路1200号2413室
研究方向：中药干预肿瘤微环境的机制研究
招生专业
院系名称 |
专业大类 |
一级学科 |
专业代码/专业名称 |
学位类型 |
招生类型 |
交叉科学研究院 |
医学 |
中药学 |
100800/中药学 |
学术学位 |
博士/硕士 |
交叉科学研究院 |
医学 |
中药学 |
105600/中药学 |
专业学位 |
硕士 |
教育及任职经历
2021.01-至今 上海中医药大学 研究员
2020.01-2020.05美国耶鲁大学 高级访问学者
2011.01-2020.12上海中医药大学 副研究员
2012.09-2013.08美国乔治华盛顿大学 高级访问学者
2007.09-2010.12上海中医药大学 助理研究员
2002.09-2007.07上海中医药大学 博士
1998.09-2002.07浙江师范大学 学士
研究方向
中药干预肿瘤微环境的机制研究。近年来围绕miRNAs在肿瘤增殖转移中的作用、巨噬细胞表型极化、肿瘤代谢及补气中药、清热解毒药对干预微环境的分子机制展开研究。
近五年以第一负责人承担的科研课题与经费
序号 |
课题类型 |
项目时间 |
项目经费 （万元） |
备注 |
1 |
国家自然科学基金面上项目 |
2018.01-2021.12 |
55 |
主持 |
2 |
国家自然科学基金面上项目 |
2016.01-2019.12 |
57 |
主持 |
代表性文章
1. Ya-Xin Lv, Hao-Ran Pan, Xin-Ying Song, Qing-Qi Chang,Dan-Dan Zhang*.Hedyotis diffusa plus Scutellaria barbata Suppress the Growth of Non-Small-Cell Lung Cancer via NLRP3/NF-κB/MAPK Signaling Pathways.Evid Based Complement Alternat Med.2021; 2021:6666499.
2. Ting Fang, Yi-Xin Jiang, Long Chen, Ling Huang, Xin-Hui Tian, Yu-Dong Zhou, Dale G Nagle,Dan-Dan Zhang*. Coix Seed Oil Exerts an Anti-Triple-Negative Breast Cancer Effect by Disrupting miR-205/S1PR1 Axis.Front Pharmacol. 2020; 11:529962.
3. Yue Yang, Ting Fang, Yi-Lan Cao, Ya-Xin Lv, Qing-Qi Chang,Dan-Dan Zhang*. Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis.Evid Based Complement Alternat Med. 2020; 2020:3587095.
4. Ting Fang, Ying-Xuan Yan, Yue Yang, Ya-Xin Lv, Qing-Qi Chang ,Dan-Dan Zhang*. Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Suppresses Migration of Bone-Metastatic Breast Cancer Cells via OPN-FAK/ERK/NF-κB Axis.Evid Based Complement Alternat Med. 2020; 2020:3573240.
5.Dan-Dan Zhang*, Yue Li, Yuan Xu, Jaejik Kim, shuang Huang*. Phosphodiesterase 7B/microRNA-200c relationship regulates triple-negative breast cancer cell growth.Oncogene.2019;38(7):1106-20.
6. Yi-Xin Jiang, Yan Chen, Yue Yang, Xiao-Xia Chen,Dan-Dan Zhang*.Screening Five Qi-Tonifying Herbs on M2 Phenotype Macrophages.Evid Based Complement Alternat Med. 2019; 2019: 9549315.
7. Yi-Xin Jiang, Yang-Yi Dai, Yi-Feng Pan, Xi-Min Wu, Yue Yang, Ka Bian,Dan-Dan Zhang*. Total Flavonoids from Radix Glycyrrhiza Exert Anti-Inflammatory and Antitumorigenic Effects by Inactivating iNOS Signaling Pathways.Evid Based Complement Alternat Med. 2018; 2018: 6714282.
8. Yuan Xu, Xiao-Xia Chen, Yi-Xin Jiang,Dan-Dan Zhang*. Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Inflammatory Effects by Regulating miR-155 Expression and JNK Signaling Pathway.Evid Based Complement Alternat Med.2018; 2018: 3593408.
9.Dan-Dan Zhang, Hong Zhang, Yuan-zhi Lao, Rong Wu, Jin-wen Xu, Ferid Murad, Ka Bian*, Hong-Xi Xu*. Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage.Mediators Inflamm.2015; 2015: 350564.
10. Xi Tan, Yuan-Lai Wang, Xiao-Lu Yang,Dan-Dan Zhang*.Ethyl Acetate Extract of Artemisia anomala S. Moore Displays Potent Anti-Inflammatory Effect.Evid Based Complement Alternat Med. 2014; 2014: 681352.
11. Chang-Liang Chen,Dan-Dan Zhang*.Anti-Inflammatory Effects of 81 Chinese Herb Extracts and Their Correlation with the Characteristics of Traditional Chinese Medicine.Evid Based Complement Alternat Med.2014; 2014: 985176.