教育背景

2003.09－2008.07 上海中医药大学博士

2004.09－2005.01 北京大学医学部进修

1999.09－2003.07 宁波大学 学士

工作经历

2020.01-今 上海中医药大学中药研究所 研究员

2011.01–2019.12 上海中医药大学中药研究所副研究员

2017.04–2018.03 哈佛大学医学院访问学者

2010.11–2014.03 上海中医药大学附属龙华医院博士后

2008.08–2010.12 上海中医药大学中药研究所助理研究员

中药抗肿瘤药理。主要针对中药/复方尤其是黄酮类成分抗肿瘤细胞/免疫细胞代谢重编程作用及机制研究。

1. YuMingzhu, PanQiaoling, LiWenbiao, DuTingting, HuangFei, WuHui, HeYixin, WuXiaojun*, ShiHailian*. Isoliquiritigenin inhibits gastric cancer growth through suppressing GLUT4 mediated glucose uptake and inducing PDHK1/PGC-1α mediated energy metabolic collapse.Phytomedicine,2023,121:155045.

2. Gai Xiao, Qian Peng, Guo Benqiong, Zheng Yixin, Fu Zhihao, Yang Decai, Zhu Chunmei, Cao Yang, Niu Jingbin, Ling Jianghong, Zhao Jin*, Shi Hailian*, Liu Guoping*.Heptadecanoic acid and pentadecanoic acid crosstalk with fecal-derived gut microbiota are potential non-invasive biomarkers for chronic atrophic gastritis.Frontiers inCellular andInfectionMicrobiology,2023,12:1064737.

3. WangPing#, JinJinmei#, LiangXiaohui,Yu Mingzhu,YangChun, HuangFei, WuHui, ZhangBeibei, FeiXiaoyan, WangZhengtao, XuRen, ShiHailian*, WuXiaojun*. Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming.Acta Pharmacologica Sinica,2022,43, 1581-1593.

4. Liang Xiaohui, Wang Ping, Yang Chun, Huang Fei, Wu Hui, Shi Hailian*, Wu Xiaojun*. Galangin inhibits gastric cancer growth through enhancing STAT3 mediated ROS production.Frontiers in Pharmacology, 2021,12:646628.

5. Wang Zhiying, Liang Xiaohui, Xiong Aizheng, Ding Lili, Li Wei, Yang Li, Wu Xiaojun, Shi Hailian*, Zhou Yue*, Wang Zhengtao. Helichrysetin and TNF-α synergistically promote apoptosis by inhibiting overactivation of the NF-κB and EGFR signaling pathways in HeLa and T98G cells.InternationalJournal ofMolecularMedicine, 2021, 47(4): 49.

6. Yin Jing#, Yi Jinyu#, Yang Chun, Xu Bo, Lin Jiang, Hu Hongyi, Wu Xiaojun, Shi Hailian*, Fei Xiaoyan*. Chronic atrophic gastritis and intestinal metaplasia induced by highsalt and NmethylN'nitroNnitrosoguanidine intake in rats.Experimental & Therapeutic Medicine,2021,21(4): 315.

7. 余明珠，潘巧岭，李文标，杜婷婷，吴辉，黄菲，吴晓俊，石海莲.参芪健胃颗粒调节能量代谢重编程抑制胃癌作用及机制.中药药理与临床. 2023. DOI:10.13412/j.cnki.zyyl.20230815.008

8. 余明珠,石海莲,吴晓俊.神经系统影响非神经系统肿瘤发生发展的研究进展.中国药理学与毒理学杂志. 2022. 36(12): 936-943.

9. 梁晓晖,石海莲*,吴晓俊*.糖代谢重编程与“炎-癌转化”及抗炎中药靶向肿瘤糖代谢抗肿瘤作用机制研究进展.中国药理学与毒理学杂志, 2021;35(11): 859-867.

10. 梁晓晖,余明珠,石海莲*,吴晓俊*.高良姜素抑制胃癌MGC803细胞NF-kB通路促进自噬.中国中药杂志.2021;46(16):4167-4174.

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先后主持国家自然科学基金、上海市自然科学基金等7项，并承担企业合作横向课题5项，另参与国家自然科学基金、教育部博士点专项优先发展领域项目等10余项。